Director Shareholding

GlaxoSmithKline PLC
5 December 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

4        Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
December Employee Trust ('the Trust'), transferred 6,138 Ordinary Shares in the
2001     Company to participants of the Glaxo Wellcome UK Share Option Scheme,
         the Glaxo Wellcome 1999 Share Option Plan and the Glaxo Wellcome
         International Share Option Scheme.



The Company was advised of these transactions on 5 December 2001.



The Trust is a discretionary trust of which all employees or former employees
of GlaxoSmithKline Services plc (formerly Glaxo Wellcome plc) and its
subsidiaries are potential beneficiaries. Two of the Company's directors, Sir
Richard Sykes and John Coombe are therefore interested in the shares held in
the Trust from time to time in the same way as other employees or former
employees of GlaxoSmithKline Services plc and its subsidiaries.



S M Bicknell

Company Secretary


5 December 2001