Director Shareholding

GlaxoSmithKline PLC
7 December 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



06       The Administrators of the GlaxoSmithKline Retirement Savings Plan
December ('the Plan') notified GlaxoSmithKline plc on the 7 December 2001, that
2001     as a result of movement in the fund on the 6 December 2001, the number
         of Ordinary Share ADRs held by the fund had decreased from 18,725,897
         to 18,709,266 at an average price of $50.8700


The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.






S M Bicknell

Company Secretary


7 December 2001