Director Shareholding

GlaxoSmithKline PLC
4 March 2002

                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


28 February 2002               The Administrators of the GlaxoSmithKline US 
                               Retirement Savings Plan ("the Plan")
                               notified GlaxoSmithKline plc on the 1 March 2002,
                               that as a result of movement in the fund on the 
                               28 February 2002, the number of Ordinary Share 
                               ADRs held by the fund had decreased from 
                               18,564,815 to 18,485,352 at an average price of 
                               $48.95.

The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One of
the Company's directors, Dr J P Garnier is therefore, interested in the shares
held in the fund from time to time in the same way as other employees or former
employees of SmithKline Beecham plc and its subsidiaries.

S M Bicknell

Company Secretary

4 March 2002



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