Director Shareholding

GlaxoSmithKline PLC
23 April 2002

                              Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


19 April 2002      The Administrators of the SmithKline Beecham Employee Benefit 
                   Trust ("the Trust") notified the Company on the 22 April 2002 
                   that 107,820 Ordinary shares had been transferred from the 
                   Trust to participants of the SmithKline Beecham 1991 Share
                   Option Plan. The Trust also sold 80 Ordinary shares at a 
                   price of £16.31 per share. The Trust also purchased 1,593 
                   Ordinary shares for participants in the SmithKline
                   Beecham Bonus Investment Plan at a price of £16.37 per share.


The Trust is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and John Coombe are therefore interested in
the shares held in the fund from time to time in the same way as other employees
or former employees of GlaxoSmithKline plc and its subsidiaries.



S M Bicknell

Company Secretary

23 April 2002




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