Director Shareholding

GlaxoSmithKline PLC
21 January 2002



                              Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

18 January 2002             Abacus (GW) Trustees Limited, as trustee of The
                            Glaxo Wellcome Employee Trust ('the Trust'),
                            transferred 4,412 Ordinary Shares in the Company to
                            participants of the Glaxo Wellcome International 
                            Share Option Scheme and the Glaxo Wellcome 1999
                            Share Option Plan.

The Company was advised of this transaction on 21 January 2002.

The Trust is a discretionary trust of which all employees or former employees of
GlaxoSmithKline Services plc (formerly Glaxo Wellcome plc) and its subsidiaries
are potential beneficiaries. Two of the Company's directors, Sir Richard Sykes
and John Coombe are therefore interested in the shares held in the Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline Services plc and its subsidiaries.

S M Bicknell

Company Secretary

21 January 2002


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