Director Shareholding

GlaxoSmithKline PLC
28 March 2002

                              Director's Interests





I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the under-mentioned directors:-

Mr John D Coombe          Exercised a nominal cost option (£1.00) on 27 March 2002 to acquire 18,087
                          shares in the Company, which had vested under the Glaxo Wellcome 1999 Long
                          Term Incentive Plan. Mr Coombe subsequently sold 7,250 of the shares so
                          acquired at a price of £16.22 per share to pay the resultant tax liability
                          and to meet the costs arising from the sale.


Sir Richard Sykes         The transfer on 27 March 2002 from a trust of which Sir Richard Sykes is a
                          trustee (The R B Sykes 1997 Discretionary trust) of a total of 2,968
                          shares in GlaxoSmithKline plc to four beneficiaries under the Trust,
                          namely Sir Richard's daughter, son and two granddaughters.

                          The sale on 27 March 2002 by a trust of which Sir Richard Sykes is a
                          trustee (The R B Sykes 1997 Discretionary Trust) of 371 shares in
                          GlaxoSmithKline plc at a price of £16.46 per share.

                          The sale on 27 March 2002 by a trust of which Sir Richard Sykes is a
                          trustee (The Lady Janet Sykes Discretionary Trust) of 371 shares in
                          GlaxoSmithKline plc at a price of £16.48 per share.



The Company was advised of these transactions on the 27 March 2002.





S M Bicknell

Company Secretary

28 March 2002



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