Director Shareholding

GlaxoSmithKline PLC
12 November 2002

                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



8 November 2002            The Administrators of the SmithKline Beecham Employee
                           Benefit Trust ("the Trust") notified the Company on 12
                           November 2002 that 71,793 Ordinary shares had been
                           transferred from the Trust to participants of the
                           SmithKline Beecham 1991 Share Option Plan, 4 shares had
                           been transferred from the Trust to a participant in the UK
                           Bonus Investment Plan and 6,176 shares had been transferred
                           from the Trust to a participant in the Annual Investment
                           Plan.


                           The Trust also sold 1,747 ordinary shares in the Company at
                           £12.55 per share on behalf of a participant in the Annual
                           Investment Plan.






The Trust is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and John Coombe are therefore interested in
the shares held in the fund from time to time in the same way as other employees
or former employees of GlaxoSmithKline plc and its subsidiaries.




S M Bicknell

Company Secretary


12 November 2002


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