Director Shareholding

GlaxoSmithKline PLC
02 December 2002

                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

Mr J D Coombe                    The grant of options over 1,031 Ordinary Shares 
                                 under the GlaxoSmithKline Savings Related Share 
                                 Option Scheme at a price of £9.16 per Ordinary 
                                 Share. The savings contract under this scheme
                                 commenced on 1 December 2002.

The Company was notified of this transaction on 2 December 2002.


S M Bicknell

Company Secretary


2 December 2002


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