Director Shareholding

GlaxoSmithKline PLC
06 December 2002

                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



4 December 2002            Abacus (GW) Trustees Limited, as trustee of The
                           GlaxoSmithKline Employee Trust, formerly The Glaxo
                           Wellcome Employee Trust, ("the GSK Trust"), converted
                           914,738 Ordinary Shares in the Company into 457,369
                           American Depository Shares (ADSs) which were
                           subsequently sold at US$37.25 per ADS.

5 December 2002            Abacus (GW) Trustees Limited, as trustee of the GSK
                           Trust, sold 840 Ordinary Shares in the Company at a
                           price of £11.8535 per Ordinary Share.

5 December 2002            Abacus (GW) Trustees Limited, as trustee of the GSK
                           Trust, sold 3,318 Ordinary Shares in the Company at a
                           price of £11.9525 per Ordinary Share.

5 December 2002            Abacus (GW) Trustees Limited, as trustee of the GSK
                           Trust, transferred 14,695 Ordinary Shares in the
                           Company to participants of the Glaxo Wellcome 1999
                           Long Term Incentive Plan.

4 December 2002            Abacus Corporate Trustee Limited, as trustee of The
                           GlaxoSmithKline (US) Trust ("the GSK US Trust"),
                           purchased 457,369 ADSs in the Company at a price of
                           US$37.25 per ADS.


The Company was advised of these transactions on 6 December 2002.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and John Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.


The GSK US Trust is a grantor trust of which all employees or former employees
of SmithKline Beecham Corporation and its subsidiaries are potential
beneficiaries. One of the Company's directors, Dr J-P Garnier is therefore
interested in the shares held in the GSK US Trust from time to time in the same
way as other employees or former employees of SmithKline Beecham Corporation and
its subsidiaries.


S M Bicknell

Company Secretary


6 December 2002


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