Director Shareholding

GlaxoSmithKline PLC
04 December 2002

                              Directors' Interests

I give below details of changes in the directors' interests in the Ordinary
Shares (Shares) and American Depositary Shares (ADSs) of GlaxoSmithKline plc.
Each ADS represents two Ordinary Shares.

On 3 December 2002, under the Rules of the GlaxoSmithKline Performance Share
Plan, Target Awards were granted over Ordinary Shares and ADSs in the Company to
the directors listed below:

                                              Ordinary Shares      American Depository
                                                                   Shares

Dr J-P Garnier                                                     70,000

Mr J D Coombe                                 40,000


On the same day, options to acquire the Company's Shares and ADSs were granted
under the GlaxoSmithKline Share Option Plan to the directors listed below:

                         Ordinary Shares        Subscription Price  American Depository     Subscription Price
                                                                    Shares

Dr J-P Garnier                                                      450,000                 $37.25

Mr J D Coombe            290,000                £11.79


Under the terms of the GlaxoSmithKline Performance Share Plan (which was
approved by Shareholders on 31 July 2000), Target Awards are granted annually to
eligible executives, designating a number of Shares/ADSs that may be awarded,
dependent upon the Company's performance over a three year measurement period.
The three year measurement period for the Target Awards granted on 3 December
2002 will commence on 1 January 2003 and end on 31 December 2005.

The grant of options is made under the GlaxoSmithKline Share Option Plan which
was approved by Shareholders on 31st July 2000. A performance condition has been
set for the vesting of the options granted to the above directors.

The Target Awards and Share Options, set out above have been granted to Dr
Garnier and Mr Coombe at the same level as last year.

S M Bicknell

Company Secretary

4 December 2002


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