Director Shareholding

GlaxoSmithKline PLC
21 October 2002



                              Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


18 October 2002  The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                 Trust") notified the Company on the 21 October 2002 that 171,755 Ordinary shares
                 had been transferred from the Trust to participants of the SmithKline Beecham
                 1991 Share Option Plan.


The Trust is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and John Coombe are therefore interested in
the shares held in the fund from time to time in the same way as other employees
or former employees of GlaxoSmithKline plc and its subsidiaries.



S M Bicknell

Company Secretary

21 October 2002


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