Director Shareholding

GlaxoSmithKline PLC
16 December 2002


                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

12 December 2002         The Administrators of the GlaxoSmithKline US Retirement 
                         Savings Plan ("the Plan") notified GlaxoSmithKline plc 
                         on 13 December 2002, that as a result of movement in 
                         the fund on the 12 December 2002, the number of 
                         Ordinary Share ADRs held by the fund had decreased from 
                         18,316,333 to 18,283,037 at an average price of $37.24.


The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Mr J D Coombe are therefore interested
in the shares held in the fund from time to time in the same way as other
employees or former employees of GlaxoSmithKline plc and its subsidiaries.


S M Bicknell

Company Secretary

16 December 2002


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