Director Shareholding

GlaxoSmithKline PLC
27 February 2003

                              Director's Interests





I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the under-mentioned directors:-


                                Mr John D Coombe     The exercise of a nominal
                                cost option (£1.00) on 25 February 2003 to
                                acquire 23,013 shares in the Company, which had
                                vested under the Glaxo Wellcome 1999 Long Term
                                Incentive Plan. Mr Coombe subsequently sold
                                9,225 of the shares so acquired at a price of
                                £11.021 per share to pay the resultant tax
                                liability and to meet the costs arising from the
                                sale.



The Company was advised of these transactions on the 27 February 2003.





SM Bicknell

Company Secretary

27 February 2003




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