Director Shareholding

GlaxoSmithKline PLC
17 February 2003


                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



14 February 2003           The Administrators of the SmithKline Beecham Employee
                           Benefit Trust ("the Trust") notified the Company on 17
                           February 2003 that 347,491 Ordinary shares had been
                           transferred from the Trust to participants of the
                           SmithKline Beecham 1991 Share Option Plan.


                           The trust also sold 20,672 ordinary shares on 13 February
                           2003 at a price of £11.025 per share.


                           The trust also sold 59 ordinary shares on 13 February 2003
                           at a price of £11.04 per share.


                           The trust also sold 142,637 ordinary shares on 13 February
                           2003 at a price of £11.025 per share.


The Trust is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and John Coombe are therefore interested in
the shares held in the fund from time to time in the same way as other employees
or former employees of GlaxoSmithKline plc and its subsidiaries.


S M Bicknell
Company Secretary

17 February 2003


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