Director Shareholding

GlaxoSmithKline PLC
22 April 2003




                              Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



17 April 2003                The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                             Trust") notified the Company on the 22 April 2003 that 2,094 Ordinary
                             shares had been purchased for participants in the SmithKline Beecham Bonus
                             Investment Plan at a price of £12.08 per share on 17 April 2003.


                             The Trust also notified the Company on 22 April 2003 that 3,284 Ordinary
                             shares had been purchased for participants in the GlaxoSmithKline Annual
                             Investment Plan on 17 April at a price of £12.08 per share.




The Trust is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and John Coombe are therefore interested in
the shares held in the fund from time to time in the same way as other employees
or former employees of GlaxoSmithKline plc and its subsidiaries.






S M Bicknell

Company Secretary


22 April 2003



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