Director Shareholding

GlaxoSmithKline PLC
07 May 2003

                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



2 May 2003                 Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           transferred 21,052 Ordinary Shares in the Company to
                           participants in the SmithKline Beecham Employee Share
                           Option Plan 1991.

5 May 2003                 The GSK Trust transferred 25,086 Ordinary Shares in
                           the Company to participants in the SmithKline Beecham
                           Employee Share Option 1991.

6 May 2003                 The GSK Trust transferred 2,761 Ordinary Shares in
                           the Company to a participant in the Glaxo Wellcome
                           1999 Long Term Incentive Plan.

6 May 2003                 The GSK Trust transferred 11,043 Ordinary Shares in
                           the Company to participants in the SmithKline Beecham
                           Employee Share Option Plan 1991.


The Company was advised of these transactions on 7 May 2003.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.


S M Bicknell

Company Secretary


7 May 2003


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