Director Shareholding

GlaxoSmithKline PLC
08 May 2003

                              Director's Interests

I give below details of changes in interests in the American Depositary Shares
(ADSs) of GlaxoSmithKline plc in respect of the under-mentioned Director:-

Dr J-P Garnier                 Exercise of options on 6 May 2003 over 28,582 
                               ADSs granted on 31 May 1994, which would have 
                               lapsed on 30 May 2004, under the SmithKline 
                               Beecham US Executive Share Option Plan 1989 at 
                               a price of $12.87052 per ADS; and the exercise 
                               of options on 7 May 2003 over 163,161 ADSs 
                               granted on 20 July 1994, which would have lapsed 
                               on 19 July 2004, under the SmithKline Beecham
                               Employee Share Option Plan 1991 at a price of 
                               $16.08708 per ADS.

                               The sale of 19,075 ADSs on 6 May 2003 at a price 
                               of $43.2317 and 115,400 ADSs on 7 May 2003 at a 
                               price of $42.133 per ADS being a total of 134,475
                               principally to cover the tax and costs arising 
                               from the option exercises.


                               As a result of these transactions Dr Garnier's 
                               shareholding in the Company has increased by 
                               57,268 ADSs (+102%) to a total of 113,283 ADSs.


The Company was advised of these transactions on 7 and 8 May 2003.


S M Bicknell

Company Secretary


8 May 2003



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