Director Shareholding

GlaxoSmithKline PLC
12 May 2003


                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


5 May 2003                 Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           transferred 40,673 Ordinary Shares in the Company to
                           participants in the SmithKline Beecham Employee Share
                           Option Plan 1991.

8 May 2003                 The GSK Trust sold 1,802 Ordinary Shares in the
                           Company on behalf of a participant in the Glaxo
                           Wellcome 1999 Long Term Incentive Plan at a price of
                           £12.9035 per share.

9 May 2003                 The GSK Trust transferred 2,581 Ordinary Shares in
                           the Company to a participant in the Glaxo Wellcome
                           1999 Long Term Incentive Plan.

9 May 2003                 The GSK Trust transferred 30,304 Ordinary shares in
                           the Company to participants of the SmithKline Beecham
                           Employee Share Option Plan 1991.


The Company was advised of these transactions on 12 May 2003.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.


S M Bicknell

Company Secretary

12 May 2003


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