Director Shareholding

GlaxoSmithKline PLC
19 September 2003


                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



18 September 2003            Abacus (GSK) Trustees Limited, as trustee of the
                             GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                             transferred 3,004 Ordinary Shares in the Company to
                             participants in the SmithKline Beecham Employee
                             Share Option Plan 1991.

18 September 2003            Abacus (GSK) Trustees Limited, as trustee of the
                             GSK Trust, transferred 20,616 Ordinary Shares in
                             the Company to participants in the SmithKline
                             Beecham Employee Share Option Plan 1991.

17 September 2003            Abacus (GSK) Trustees Limited, as trustee of the
                             GSK Trust, transferred 17,488 Ordinary Shares in
                             the Company to participants in the SmithKline
                             Beecham Employee Share Option Plan 1991.




The Company was advised of these transactions on 19 September 2003.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.


S M Bicknell

Company Secretary


19 September 2003


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