Director Shareholding

GlaxoSmithKline PLC
22 December 2003

                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


17 December 2003       The Administrators of the SmithKline Beecham Employee
                       Benefit Trust notified the Company on 22 December 2003
                       that 1,574 Ordinary shares had been transferred from the
                       Trust to participants in the GlaxoSmithKline Annual
                       Investment Plan.


The Trust is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and John Coombe are therefore interested in
the shares held in the fund from time to time in the same way as other employees
or former employees of GlaxoSmithKline plc and its subsidiaries.


S M Bicknell
Company Secretary

22 December 2003


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