Director Shareholding

GlaxoSmithKline PLC
23 December 2003

                              Directors' Interests

I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned directors:

Sir Christopher Hogg acquired a beneficial interest in 28 Ordinary Shares
purchased under a Personal Equity Plan on 22 December 2003 at £12.57.

Mr J D Coombe acquired a     beneficial interest in 9 Ordinary Shares purchased
under a Personal Equity Plan on 22 December 2003 at £12.57.

Mrs G A Coombe (wife of Mr J D Coombe) acquired a beneficial interest in 7
Ordinary Shares purchased under a Personal Equity Plan on 22 December 2003 at
£12.57.

Sir Peter Job acquired a beneficial interest in 1 Ordinary Share purchased under
a Personal Equity Plan on 22 December 2003 at £12.57.


The Directors and the Company were advised of these transactions on 23 December
2003.



S M Bicknell

Company Secretary

23 December 2003



                      This information is provided by RNS
            The company news service from the London Stock Exchange