Director Shareholding

GlaxoSmithKline PLC
12 November 2003

                              Director's Interests

I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £12.87 per Ordinary Share on 11
November 2003 through the Company's ShareReward Plan ("the Plan") which Mr
Coombe entered on 5 October 2001:

Mr J D Coombe                      Acquisition of 10 Ordinary Shares under the partnership element of the
                                   Plan (personal contribution)

                                   Acquisition of 10 Ordinary Shares under the matching element of the Plan
                                   (Company contribution)

Mr Coombe and the Company were advised of this information on 12 November 2003.


S M Bicknell

Company Secretary

12 November 2003


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