Director Shareholding

GlaxoSmithKline PLC
29 September 2003





                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


26 September 2003              Abacus (GSK) Trustees Limited, as trustee of the
                               GlaxoSmithKline Employee Trust, ("the GSK
                               Trust"), transferred 8,338 Ordinary Shares in
                               the Company to participants in the SmithKline
                               Beecham Employee Share Option Plan 1991.



The Company was advised of this transaction on 29 September 2003.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.

S M Bicknell

Company Secretary

29 September 2003


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