Director Shareholding

GlaxoSmithKline PLC
07 October 2003



                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



1 October 2003             Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           transferred 3,173 Ordinary Shares in the Company on
                           behalf of participants in the SmithKline Beecham Mid
                           Term Incentive Plan.

1 October 2003             The GSK Trust sold 651 Ordinary Shares in the Company
                           on behalf of participants in the SmithKline Beecham
                           Mid Term Incentive Plan at a price of £12.513 per
                           share.

3 October 2003             The GSK Trust transferred 13,382 Ordinary Shares in
                           the Company on behalf of participants in the
                           SmithKline Beecham Employee Share Option Plan 1991.




The Company was advised of these transactions on 6 October 2003.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.


S M Bicknell

Company Secretary


7 October 2003


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