Director Shareholding

GlaxoSmithKline PLC
10 October 2003



                              Director's Interests


I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £12.96 per Ordinary Share on 9 October
2003 through the Company's ShareReward Plan ("the Plan") which Mr Coombe entered
on 5 October 2001:
                    
Mr J D Coombe            Acquisition of 9 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 9 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)

Mr Coombe and the Company were advised of this information on 10 October 2003.


S M Bicknell

Company Secretary

10 October 2003


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