Director Shareholding

GlaxoSmithKline PLC
11 February 2004


                              Directors Interests

I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £11.79 per Ordinary Share on 10
February 2004 through the Company's ShareReward Plan ("the Plan") which Mr
Coombe entered on 5 October 2001:



Mr J D Coombe      Acquisition of 11 Ordinary Shares under the 
                   partnership element of the Plan (personal contribution)

                   Acquisition of 11 Ordinary Shares under the matching 
                   element of the Plan (Company contribution)

Mr Coombe and the Company were advised of this information on 11 February 2004.






S M Bicknell

Company Secretary


11 February 2004


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