Director Shareholding

GlaxoSmithKline PLC
25 February 2004

                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

23 February 2004             The Administrators of the SmithKline Beecham 
                             Employee Benefit Trust ("the Trust") notified the 
                             Company on 25 February 2004 that 7,702 Ordinary 
                             shares had been transferred from the Trust to 
                             participants in the SmithKline Beecham Bonus 
                             Investment Plan.

The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.


S M Bicknell

Company Secretary


25 February 2004



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