Director Shareholding

GlaxoSmithKline PLC
18 February 2004


                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


17 February 2004             Abacus (GSK) Trustees Limited, as trustee of the
                             GlaxoSmithKline Employee Trust, ("GSK Trust"),
                             converted 190,282 Ordinary Shares in the Company to
                             95,141 ADSs which were subsequently transferred to
                             participants in the GlaxoSmithKline Performance
                             Share Plan.

17 February 2004             Abacus (GSK) Trustees Limited, as trustee of the
                             GSK Trust, transferred 277,348 Ordinary Shares in
                             the Company to participants in the GlaxoSmithKline
                             Performance Share Plan.

17 February 2004             Abacus Corporate Trustee Limited, as trustee of the
                             GlaxoSmithKline US Trust, ("GSK US Trust"),
                             transferred 3,913 ADSs in the Company to
                             participants in the GlaxoSmithKline Performance
                             Share Plan.

The Company was advised of these transactions on 18 February 2004.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

The GSK US Trust is a grantor trust of which all employees or former employees
of SmithKline Beecham Corporation and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Dr T Yamada
are therefore interested in the shares held in the GSK US Trust from time to
time in the same way as other employees or former employees of SmithKline
Beecham Corporation and its subsidiaries.

S M Bicknell

Company Secretary

18 February 2004


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