Director Shareholding

GlaxoSmithKline PLC
20 February 2004





                              Director's Interests



I give below details of changes in interests in the American Depositary Shares
(ADSs) of GlaxoSmithKline plc in respect of the under-mentioned Director:-


Dr J-P Garnier                  Exercise of options on 19 February 2004 over 117,259 ADSs granted on 22
                                November 1994, which would have lapsed on 22 November 2004, under the
                                SmithKline Beecham US Executive Share Option Plan 1989 at a price of
                                $14.5305 per ADS; and the exercise of options on 19 February 2004 over
                                113,793 ADSs granted on 22 November 1994, which would have lapsed on 22
                                November 2004, under the SmithKline Beecham Employee Share Option Plan 1991
                                at a price of $14.5305 per ADS.

                                The sale of 142,250 ADSs on 19 February 2004 at a price of $43.1866
                                principally to cover the tax and costs arising from the option exercises.

                                As a result of these transactions Dr Garnier's shareholding in the Company
                                has increased by 88,802 ADSs (78%) to a total of 203,167 ADSs.



The Company was advised of these transactions on 19 February 2004.

S M Bicknell

Company Secretary

20 February 2004


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