Director Shareholding

GlaxoSmithKline PLC
27 February 2004



                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


          The Administrators of the GlaxoSmithKline US Retirement
          Savings Plan ("the Plan") notified GlaxoSmithKline plc on 27
          February 2004, that as a result of movement in the fund on
          26 February 2004, the number of Ordinary Share ADRs held by
          the fund had decreased from 18,670,390 to 18,625,106 at an
          average price of $42.72.




The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.




S M Bicknell
Company Secretary


27 February 2004


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