Director Shareholding

GlaxoSmithKline PLC
16 April 2004


                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


14 April 2004                Abacus (GSK) Trustees Limited, as trustee of the
                             GlaxoSmithKline Employee Trust, ("GSK Trust"),
                             transferred 48,347 Ordinary Shares in the Company
                             to participants in the SmithKline Beecham Employee
                             Share Option Plan 1991.


15 April 2004                Abacus (GSK) Trustees Limited, as trustee of the
                             GSK Trust, transferred 770,264 Ordinary Shares in
                             the Company to participants in the SmithKline
                             Beecham Employee Share Option Plan 1991.


The Company was advised of this transaction on 16 April 2004.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.


S M Bicknell
Company Secretary

16 April 2004


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