Director Shareholding

GlaxoSmithKline PLC
16 April 2004


                              Directors' Interests

I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Directors or connected
persons, arising from the purchase of Ordinary Shares on 15 April 2004 under a
Single Company ISA at a price of £11.39 per Ordinary Share:

Mr J D Coombe                       5

Mrs G A Coombe                      5
(wife of Mr J D Coombe)

Sir Peter Job                      10


The Company and Directors were advised of this information on 16 April 2004.


S M Bicknell
Company Secretary

16 April 2004



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