Director Shareholding

GlaxoSmithKline PLC
21 April 2004



                              Directors' Interests


The Administrators of the GlaxoSmithKline Executive Supplemental Savings Plan
notified the Company and the under-mentioned Directors on 20 April 2004 of
changes in their interests in Ordinary Share ADRs arising from an increase in
their interests under the Annual Investment Plan feature following the
re-investment of the dividend paid to shareholders on 15 April 2004 at a price
of $42.66 per share:-


Dr J P Garnier                                                  442

Dr T Yamada                                                     285


S M Bicknell

Company Secretary

21 April 2004


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