Director Shareholding

GlaxoSmithKline PLC
19 March 2004

                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

          The Administrators of the GlaxoSmithKline US Retirement
          Savings Plan ("the Plan") notified GlaxoSmithKline plc on 19
          March 2004, that as a result of movement in the fund on 18
          March 2004, the number of Ordinary Share ADRs held by the
          fund had decreased from 18,925,448 to 18,865,547 at an
          average price of $39.63.

The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.

S M Bicknell
Company Secretary

19 March 2004


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