Director Shareholding

GlaxoSmithKline PLC
18 May 2004


                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


          The Administrators of the GlaxoSmithKline US Retirement
          Savings Plan ("the Plan") notified GlaxoSmithKline plc on 17
          May 2004, that as a result of movement in the fund on 14 May
          2004, the number of Ordinary Share ADRs held by the fund had
          decreased from 18,870,513 to 18,866,129 at an average price
          of $41.95.


The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.


S M Bicknell
Company Secretary

18 May 2004


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