Director Shareholding

GlaxoSmithKline PLC
13 January 2004

                              Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



9 January 2004               The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                             Trust") notified the Company on the 12 January 2004 that 1,330 Ordinary
                             shares had been purchased for participants in the SmithKline Beecham Bonus
                             Investment Plan at a price of £12.18 per share.


                             The Trust also notified the Company on 12 January 2004 that 4,465 Ordinary
                             shares had been purchased for participants in the GlaxoSmithKline Annual
                             Investment Plan at a price of £12.17 per share.




The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.






S M Bicknell

Company Secretary


13 January 2004



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