Director Shareholding

GlaxoSmithKline PLC
13 January 2004


                              Director's Interests


I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £12.18 per Ordinary Share on 12
January 2004 through the Company's ShareReward Plan ("the Plan") which Mr Coombe
entered on 5 October 2001:


Mr J D Coombe                      Acquisition of 10 Ordinary Shares under the partnership element of the
                                   Plan (personal contribution)

                                   Acquisition of 10 Ordinary Shares under the matching element of the Plan
                                   (Company contribution)


Mr Coombe and the Company were advised of this information on 13 January 2004.


S M Bicknell

Company Secretary


13 January 2004


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