Director Shareholding

GlaxoSmithKline PLC
30 April 2004


                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


          The Administrators of the GlaxoSmithKline US Retirement
          Savings Plan ("the Plan") notified GlaxoSmithKline plc on 30
          April 2004, that as a result of movement in the fund on 29
          April 2004, the number of Ordinary Share ADRs held by the
          fund had decreased from 18,794,940 to 18,793,310 at an
          average price of $41.45.




The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.




S M Bicknell

Company Secretary


30 April 2004


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