Director Shareholding

GlaxoSmithKline PLC
17 March 2004





                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



15 March 2004                Abacus (GSK) Trustees Limited, as trustee of the
                             GlaxoSmithKline Employee Trust, ("GSK Trust"),
                             purchased 368 American Depository Shares (ADS) in
                             the Company on behalf of participants in the
                             GlaxoSmithKline Performance Share Plan at a price
                             of $40.23456 per ADS.

15 March 2004                Abacus (GSK) Trustees Limited as trustee of the GSK
                             Trust transferred 368 American Depository Shares
                             (ADS) in the Company to participants in the
                             GlaxoSmithKline Performance Share Plan.


The Company was advised of these transactions on 17 March 2004.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.


S M Bicknell

Company Secretary

17 March 2004


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