Director Shareholding

GlaxoSmithKline PLC
16 July 2004

                              
                              Director's Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


12 July 2004        The Administrators of the SmithKline Beecham Employee 
                    Benefit Trust ("the Trust") notified the Company on 15 July 
                    2004 that following re-investment of the cash dividend paid 
                    to the shareholders on 1 July 2004, 1,287 Ordinary shares in 
                    the Company had been purchased for participants in the 
                    SmithKline Beecham Bonus Investment Plan at a price of 
                    £10.82 and that 1,334 Ordinary Shares had been transferred 
                    to a participant in the SmithKline Beecham Bonus Investment 
                    Plan.

                    The Trust also notified the Company on 15 July that 
                    following reinvestment of the cash dividend paid to 
                    shareholders on 1 July 2004, 9,075 Ordinary shares in the 
                    Company had been purchased for participants in the 
                    GlaxoSmithKline Annual Investment Plan at a price of £10.82.  
                    The Trust also notified the Company on 15 July that 1,651 
                    Ordinary Shares had been transferred to participants of the 
                    Annual Investment Plan.


The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.


S M Bicknell
Company Secretary

16 July 2004




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