Director Shareholding

GlaxoSmithKline PLC
01 October 2004



                              Directors' Interests


I give below details of changes in the directors' interests in the Ordinary
Shares and American Depository Shares (ADSs) of GlaxoSmithKline plc.

On 1 October 2004, the following non-executive Directors were provisionally
allocated the following awards over Ordinary Shares and ADSs in the Company
under the automatic share allocation arrangements for non-executive Directors
for the period of service from 1 July to 30 September 2004, as listed below.


Non Executive Director                     Ordinary Shares        American Depository Shares
                                                                             (ADS)
Sir Christopher Hogg                            1,500
Sir Christopher Gent                          1254.88009
Mr Lawrence Culp                                                              125
Mr Crispin Davis                                 250
Sir Peter Job                                    250
Sir Deryck Maughan                                                            125
Sir Ian Prosser                                  250
Dr Ronaldo Schmitz                               250
Dr Lucy Shapiro                                                               125
Sir Robert Wilson                                250



At the same time the following non-executive Directors were provisionally
allocated the following awards over Ordinary Shares and ADSs in the Company
under the share election element of the share allocation arrangements for
non-executive Directors for the period of service from 1 July to 30 September
2004, as listed below.


Non Executive Director                     Ordinary Shares        American Depositary Shares
                                                                             (ADS)

Sir Christopher Hogg                          3,137.2002
Mr Lawrence Culp                                                           412.5602
Mr Crispin Davis                               941.1601
Sir Peter Job                                  941.1601
Sir Deryck Maughan                                                         548.5691
Sir Ian Prosser                                 470.58
Dr Ronaldo Schmitz                             460.1227



The Company and the directors were informed of these allocations on 1 October
2004.


S M Bicknell
Company Secretary
1 October 2004


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