Director Shareholding

GlaxoSmithKline PLC
04 October 2004



                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


1 October 2004       Abacus (GSK) Trustees Limited, as trustee of the
                     GlaxoSmithKline Employee Trust, ("GSK Trust"), transferred
                     7,686 Ordinary Shares in the Company to participants in the
                     SmithKline Beecham Employee Share Option Plan 1991.


The Company was advised of this transaction on 4 October 2004.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.


S M Bicknell
Company Secretary


4 October 2004





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