Director Shareholding

GlaxoSmithKline PLC
05 October 2004


                              Director's Interests

I give below details of changes in interests in the Ordinary Shares and American
Depositary Receipts (ADRs) of GlaxoSmithKline plc in respect of the
under-mentioned directors:-


Dr J P Garnier       The Administrators of the GlaxoSmithKline Performance Share Plan
                     notified the Company and Dr Garnier on 4 October 2004 that his interest
                     had notionally increased by 1,822.957 ADRs at a price of $40.98 per ADR
                     following the notional re-investment of the dividend paid to
                     shareholders on 30 September 2004.


Dr T Yamada          The Administrators of the GlaxoSmithKline Performance Share Plan
                     notified the Company and Dr Yamada on 4 October 2004 that his interest
                     had notionally increased by 546.887 ADRs at a price of $40.98 per ADR
                     following the notional re-investment of the dividend paid to
                     shareholders on 30 September 2004.


Mr J D Coombe        The Administrators of the GlaxoSmithKline Performance Share Plan
                     notified the Company and Mr Coombe on 4 October 2004 that his interest
                     had notionally increased by 1,105.739 Ordinary Shares at a price of
                     £11.08 per Ordinary Share following the notional re-investment of the
                     dividend paid to shareholders on 30 September 2004.





The notional dividends accrued will be paid out in proportion to the percentage
of participants' Performance Share Plan holdings that vest following the end of
the relevant three year measurement period.



S M Bicknell
Company Secretary



5 October 2004


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