Director Shareholding

GlaxoSmithKline PLC
05 July 2004


                           Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc:

               The Administrators of the GlaxoSmithKline US Retirement Savings 
               Plan ("the Plan") notified GlaxoSmithKline plc on 2 July 2004, 
               that as a result of a recalculation of the fund on 1 July 2004, 
               the number of Ordinary Share ADRs held by the fund had changed 
               from 18,976,794 to 18,996,800 at an average price of $42.64.

The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.

S M Bicknell
Company Secretary

5 July 2004


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