Director Shareholding

GlaxoSmithKline PLC
10 August 2004


Director's Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




9 August 2004     The Administrators of the SmithKline Beecham Employee 
                  Benefit Trust ("the Trust") notified the Company on 10 August 
                  2004 that 514 Ordinary shares had been transferred from the 
                  Trust to a participant in the GlaxoSmithKline Annual
                  Investment Plan.


The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.



S M Bicknell
Company Secretary



10 August 2004




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