Director Shareholding

GlaxoSmithKline PLC
11 August 2004


                              Director's Interests


I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £10.72 per Ordinary Share on 10 August
2004 through the Company's ShareReward Plan ("the Plan") which Mr Coombe entered
on 5 October 2001:

Mr J D Coombe            Acquisition of 12 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 12 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)

Mr Coombe and the Company were advised of this information on 11 August 2004.


S M Bicknell
Company Secretary

11 August 2004


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