Director Shareholding

GlaxoSmithKline PLC
23 August 2004


                              Directors' Interests

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan, which is notionally held in GSK Ordinary
Share ADRs, the Administrators of the Plan notified GlaxoSmithKline plc and the
under-mentioned Directors on 23 August 2004 of an increase in the notional
allocation of Ordinary Share ADRs on 05 August 2004 at a price of $40.18 per
share:-


Dr J P Garnier                                                         47
Dr T Yamada                                                            16



S M Bicknell
Company Secretary
23 August 2004


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