Director Shareholding

GlaxoSmithKline PLC
02 August 2004


Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc:

               The Administrators of the GlaxoSmithKline US Retirement Savings 
               Plan ("the Plan") notified GlaxoSmithKline plc on 2 August 2004, 
               that as a result of a movement in the fund on 30 July 2004, the 
               number of Ordinary Share ADRs held by the fund had changed from 
               18,974,638 to 19,033,495 at an average price of $40.67.


The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.


S M Bicknell
Company Secretary

2 August 2004


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