Director Shareholding

GlaxoSmithKline PLC
10 September 2004


                             Director's Interests

I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £11.50 per Ordinary Share on 9
September 2004 through the Company's ShareReward Plan ("the Plan") which Mr
Coombe entered on 5 October 2001:

Mr J D Coombe            Acquisition of 11 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 11 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)

Mr Coombe and the Company were advised of this information on 10 September 2004.


S M Bicknell

Company Secretary


10 September 2004


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