Director Shareholding

GlaxoSmithKline PLC
13 September 2004



                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc:


The Administrators of the GlaxoSmithKline US Retirement Savings Plan ("the Plan") notified GlaxoSmithKline plc on 13
September 2004, that as a result of a movement in the fund on 10 September 2004, the number of Ordinary Share ADRs held
by the fund had changed from 19,146,649 to 19,181,782 at an average price of $41.50.


The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.





S M Bicknell
Company Secretary



13 September 2004


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